The long-term objective of the group is to understand genome function and evolution with the focus on epigenetics, developmental biology, and DNA mutability. In our work we use computational approaches and collaborate extensively with bench scientists.

Here are some questions which we tackle in the lab:
-- how transcriptional regulators identify their targets within a highly compacted genome of billions of nucleotides?
-- how genes are regulated with the reliability of a well-tuned machine across multiple tissues and developmental stages and what goes wrong in disease?
-- how chromatin organization varies in organisms with different genome complexities across the evolutionary scale?

Progress in high-throughput technologies, including next generation sequencing, allowed addressing these questions on genome scale. We develop methods for processing and analysis of such data and apply these methods to relevant biological and biomedical questions. Specifically we are interested in how primary structure of chromatin – assembly of genomic DNA, RNA and proteins – mediates gene regulation in normal development and disease.

Our papers at journal covers: